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KMID : 1007520010100030278
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Food Science and Biotechnology
2001 Volume.10 No. 3 p.278 ~ p.281
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Effect of Apple Pomace on the Liver Damage in Bromobenzene - treated Rats
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Lee, Jae Ho
Kim, Young Chan/Chung, Shin Kyo/Kim, Mi Yeon/Lee, Hye Sung/Kim, Kye Ok/Sohn, Yoon Kyung
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Abstract
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Sprague-Dawley rats were fed with AIN-76 diet containing 10% cellulose. In experimental diet for apple pomace powder fed groups (APB), the cellulose portion was replaced with the same amount of apple pomace powder, while that for apple pomace ethyl acetate extract fed group (AEB), ethyl acetate extract (50 ㎎/㎏) was orally administrated at the same time once a day. Upon 6 weeks of feeding, bromobenzene treated (500 ㎎/㎏) rats were sacrificed, and the liver was removed. The lipid peroxide values in the liver of AEB were lower than those of control group (CON) and bromobenzene treated group (BRB) groups. The glutathione (GSH) contents of APB and AEB groups were significantly higher than CON group. Activities of glutathione S-transferase (GST) were also higher in BRB, APB, and AEB groups. AEB and APB groups showed milder necrosis of hephatocytes than BRB group as revealed through the histological observation of rat liver tissue. Ethyl acetate extract and apple pomace powder were assumed to have protective effect against the bromobenzene-induced hepatotoxicity.
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